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Digoxin: Coadministration of multiple once-daily doses of saxagliptin (10 mg) and digoxin (0 buy silagra online erectile dysfunction wellbutrin xl. Simvastatin: Coadministration of multiple once-daily doses of saxagliptin (10 mg) and simvastatin (40 mg) cheap 50 mg silagra overnight delivery erectile dysfunction cancer, a CYP3A4/5 substrate silagra 50mg with mastercard impotence by smoking, increased the Cof saxagliptin before 21% order 50 mg silagra otc impotence at 70; manner, the AUC of saxagliptin was unchanged. Diltiazem: Coadministration of a single dose of saxagliptin (10 mg) and diltiazem (360 mg long-acting formulation at unrelieved affirm), a run inhibitor of CYP3A4/5, increased the Cof saxagliptin through 63% and the AUC nearby 2. This was associated with a corresponding lowering in the Cand AUC of the full metabolite nearby 44% and 36%, separately. Ketoconazole: Coadministration of a isolated dosage of saxagliptin (100 mg) and ketoconazole (200 mg every 12 hours at steady splendour), a vigorous inhibitor of CYP3A4/5 and P-gp, increased the Cfor saxagliptin through 62% and the AUC by 2. This was associated with a corresponding taper off in the Cand AUC of the active metabolite by 95% and 91%, severally. In another muse about, coadministration of a cull amount of saxagliptin (20 mg) and ketoconazole (200 mg every 12 hours at relentless stage), increased the Cand AUC of saxagliptin by 2. This was associated with a corresponding decrease in the Cand AUC of the running metabolite at near 96% and 90%, respectively. Rifampin: Coadministration of a put portion of saxagliptin (5 mg) and rifampin (600 mg QD at undeviating state) decreased the Cand AUC of saxagliptin via 53% and 76%, respectively, with a corresponding heighten in C(39%) but no noteworthy change in the plasma AUC of the active metabolite. Omeprazole: Coadministration of multiple once-daily doses of saxagliptin (10 mg) and omeprazole (40 mg), a CYP2C19 (significant) and CYP3A4 substrate, an inhibitor of CYP2C19, and an inducer of MRP-3, did not revise the pharmacokinetics of saxagliptin. Aluminum hydroxide + magnesium hydroxide + simethicone: Coadministration of a free quantity of saxagliptin (10 mg) and a fluent containing aluminum hydroxide (2400 mg), magnesium hydroxide (2400 mg), and simethicone (240 mg) decreased the Cof saxagliptin on 26%; in spite of that, the AUC of saxagliptin was unchanged. Famotidine: Administration of a choose measure of saxagliptin (10 mg) 3 hours after a solitary administer of famotidine (40 mg), an inhibitor of hOCT-1, hOCT-2, and hOCT-3, increased the Cof saxagliptin at hand 14%; on the other hand, the AUC of saxagliptin was unchanged. Saxagliptin did not induce tumors in either mice (50, 250, and 600 mg/kg) or rats (25, 75, 150, and 300 mg/kg) at the highest doses evaluated.

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